In anaerobic glycolysis, which cofactor is regenerated to allow glycolysis to continue?

Study for the IMAT Biology Exam with focused multiple-choice questions. Use hints and explanations to enhance your preparation. Get ready for your exam success!

Multiple Choice

In anaerobic glycolysis, which cofactor is regenerated to allow glycolysis to continue?

Explanation:
NAD+. In glycolysis, the step that oxidizes glyceraldehyde-3-phosphate relies on NAD+ to accept electrons, forming NADH. For glycolysis to keep running, NADH must be converted back to NAD+. Under anaerobic conditions, this happens when pyruvate is reduced to lactate (in animals) or to ethanol (in yeast), reoxidizing NADH to NAD+. This regeneration of NAD+ lets glycolysis continue and provides a quick supply of ATP without oxygen. NADP+, FAD, and ATP don’t serve this NAD+ regeneration role in anaerobic glycolysis.

NAD+. In glycolysis, the step that oxidizes glyceraldehyde-3-phosphate relies on NAD+ to accept electrons, forming NADH. For glycolysis to keep running, NADH must be converted back to NAD+. Under anaerobic conditions, this happens when pyruvate is reduced to lactate (in animals) or to ethanol (in yeast), reoxidizing NADH to NAD+. This regeneration of NAD+ lets glycolysis continue and provides a quick supply of ATP without oxygen. NADP+, FAD, and ATP don’t serve this NAD+ regeneration role in anaerobic glycolysis.

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